All posts by Eva

Doctoral thesis on new Chiral Solvating Agents based on molecular tweezers

Last July I defended the doctoral thesis entitledNous agents de solvatació quiral tipus pinça amb anells antracènics: derivats de trifluorometilamines i trifluorometilcarbinols binòlics”.

The thesis focuses on the synthesis and behaviour of new Chiral Solvating Agents (CSA) based on molecular tweezers. The newly synthesized enantiopure compounds can be classified in two big groups:

  • the ones with a trifluoromethylanthrylamine backbone and an isopthalyc acid  as a linking molecule, and
  • the trifluoromethylcarbinol derivatives linked by a BINOL molecule, which adds an additional stereogenic element due to its chiral axis.

Continue reading Doctoral thesis on new Chiral Solvating Agents based on molecular tweezers

What is DNP? Obtaining enhanced NMR signals for in-vitro and in-vivo applications

Dynamic Nuclear Polarization is the method for obtaining strongly polarised nuclear spins, resulting in enhanced NMR signals for 13C and 15N nuclei in solution-state

Our NMR facility (SeRMN) has recently installed a HyperSense® (Oxford Instruments), a new instrument capable of delivering a huge sensitivity enhancement for your in-vitro and in-vivo applications allowing an easy and quick switching between both applications.

Liquid-state NMR spectroscopy is an important technique into a wide range of applications. However, it is limited by an intrinsically lack of sensitivity due to the low gyromagnetic ratio and natural abundance of the nuclei usually under study (13C, 15N, etc.) as compared with other analytical methods. Continue reading What is DNP? Obtaining enhanced NMR signals for in-vitro and in-vivo applications