The Specialised Group of NMR of the Spanish Royal Society of Chemistry (GERMN, RSEQ) organizes the XV Manuel Rico NMR Summer School in Jaca from 19th-23th June 2023.
This well-established bi-annual summer course is aimed at PhD students, postdocs, technical staff of NMR facilities and, in general, to researchers from academy and industry interested in deepening their understanding of NMR. The course covers theoretical aspects, state-of-the-art methods and applications in fields as diverse as Molecular Chemistry, Materials, Biology, Medicine, and Pharmaceutical Industry, including solution-state, and solid-state NMR techniques, as well as MRI techniques.
Silvia Lope, SeRMN staff, will be teaching a class in “Magnetic Resonance Imaging”.
The Specialised Group of NMR of the Spanish Royal Society of Chemistry (GERMN, RSEQ) organizes the XIV Manuel Rico NMR Summer School in Jaca from 19th-24th June 2022.
This well-established bi-annual summer course is aimed at PhD students, postdocs, technical staff of NMR facilities and, in general, to researchers from academy and industry interested in deepening their understanding of NMR. The course covers theoretical aspects, state-of-the-art methods and applications in fields as diverse as Molecular Chemistry, Materials, Biology, Medicine, and Pharmaceutical Industry, including solution-state, and solid-state NMR techniques, as well as MRI techniques.
Silvia Lope, SeRMN staff, will be teaching a class in “Magnetic Resonance Imaging”.
End of pre-registration April 12th, 2022
Start of Registration: April 30th, 2022
End of Registration: May 17th, 2022
For detailed information please visit their webpage https://rmnjaca22.iqfr.csic.es/
Workshop limited to 4 participants (first come, first served)
Contact person:
Silvia Lope-Piedrafita, PhD ()
This course combines a comprehensive series of lectures on the technology of Magnetic resonance spectroscopy and imaging (MRS/MRI) with hands-on laboratory sessions to provide practical demonstrations of key concepts and procedures for preclinical studies.
Whether you are considering MRI as a research tool in your lab or just would like to learn more about MRI, this workshop addresses practical aspects of experimental MRI with laboratory animals and provide valuable hands-on experience on a 7 Tesla Bruker BioSpec spectrometer.
Workshop limited to 4 participants (first come, first served)
Contact person:
Silvia Lope-Piedrafita, PhD ()
This course combines a comprehensive series of lectures on the technology of Magnetic resonance spectroscopy and imaging (MRS/MRI) with hands-on laboratory sessions to provide practical demonstrations of key concepts and procedures for preclinical studies.
Whether you are considering MRI as a research tool in your lab or just would like to learn more about MRI, this workshop addresses practical aspects of experimental MRI with laboratory animals and provide valuable hands-on experience on a 7 Tesla Bruker BioSpec spectrometer.
Progression of Alzheimer’s disease and effect of scFv-h3D6 immunotherapy in the 3xTg-AD mouse model: An in vivo longitudinal study using Magnetic Resonance Imaging and Spectroscopy by Güell-Bosch J, Lope-Piedrafita S, Esquerda-Canals G, Montoliu-Gaya L, and Villegas S. NMR in Biomedicine 33(5):e4263; DOI: 10.1002/nbm.4263.
Alzheimer’s disease (AD) is an incurable disease that affects most of the 47 million people estimated as living with dementia worldwide. The main histopathological hallmarks of AD are extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein. In recent years, Aβ-immunotherapy has been revealed as a potential tool in AD treatment. One strategy consists of using single-chain variable fragments (scFvs), which avoids the fragment crystallizable (Fc) effects that are supposed to trigger a microglial response, leading to microhemorrhages and vasogenic edemas, as evidenced in clinical trials with bapineuzumab. The scFv-h3D6 generated by our research group derives from this monoclonal antibody, which targets the N-terminal of the Aβ peptide and recognizes monomers, oligomers and fibrils.
In this study, 3xTg-AD mice were intraperitoneally and monthly treated with 100 μg of scFv-h3D6 (a dose of ~3.3 mg/kg) or PBS, from 5 to 12 months of age (-mo), the age at which the mice were sacrificed and samples collected for histological and biochemical analyses. During treatments, four monitoring sessions using magnetic resonance imaging and spectroscopy (MRI/MRS) were performed at 5, 7, 9, and 12 months of age. MRI/MRS techniques allow, in a non-invasive manner, to draw an in vivo picture of concrete aspects of the pathology and to monitor its development across time. Compared with the genetic background, 3xTg-AD mice presented a smaller volume in almost all cerebral regions and ages examined, an increase in both the intra and extracellular Aβ1-42 at 12-mo, and an inflammation process at this age, in both the hippocampus (IL-6 and mIns) and cortex (IL-6). In addition, treatment with scFv-h3D6 partially recovered the values in brain volume, and Aβ, IL-6, and mIns concentrations, among others, encouraging further studies with this antibody fragment.
Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis
and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION)
show good performance as transverse relaxation (T2) contrast agents, thus
facilitating the interpretation of the acquired images. Attachment of SPION
onto nanocarriers prevents their agglomeration, improving the circulation time
and efficiency. Graphene derivatives, such as graphene oxide (GO) and reduced
graphene oxide (RGO), are appealing nanocarriers since they have both high
surface area and functional moieties that make them ideal substrates for the
attachment of nanoparticles. A fast, simple, and environmentally friendly
microwave-assisted approach for the synthesis of SPION-RGO hybrids has been demonstrated
in this study. Different iron precursor/GO ratios were used leading to SPION,
with a median diameter of 7.1 nm, homogeneously distributed along the RGO
surface. Good relaxivity (r2*) values were obtained in MRI studies and no
significant toxicity was detected within in vitro tests following GL261 glioma
and J774 macrophage-like cells for 24 h with SPION-RGO, demonstrating the
applicability of the hybrids as T2-weighted MRI contrast agents.
We are recruiting an Early Stage Researcher to work on a decision-support system based on MRSI data at 3T, for glioblastoma therapy response follow- up, as part of the INSPiRE-MED European project.
We seek a highly motivated and qualified individual as Early Stage Researcher for a three-year applied research project. The successful candidate will contribute to the development of advanced biomedical research tools in the field of Magnetic Resonance Spectroscopy and Imaging, and its application to the clinical day-to-day practice.
Project description: This position is one of the 15 ESR positions of the INSPiRE-MED European Training Network, which focuses on the development of Magnetic Resonance Spectroscopy (MRS) and MR Spectroscopic Imaging (MRSI) combined with Positron Emission Tomography (PET), enhanced by machine learning techniques.
The main aim of the PhD project (ESR12) will be development of a Machine Learning medical decision-support system based on MRSI data at 3T, for glioblastoma therapy response follow-up.
The
ESR will develop a novel medical decision support system (MDSS)
focused on glioblastoma therapy response follow-up, based on magnetic
resonance spectroscopic imaging (MRSI) data, able to take and process
data from multiple MRSI formats and centres. For each patient’s
MRSI, the MDSS should deliver a nosological or classification image,
ready to be fused with images of other MR modalities from the same
patient. The DSS will be integrated into the interface of the
academic version of jMRUI, in a way that allows clinicians evaluate
the system with their data. An important part of of the project will
be the incorporation of automated MRSI artifact detection and removal
tools.
Official call by Universitat Autònoma de Barcelona
Deadline for submissions: 21/5/2019 at 23:00
See UAB and/or Euraxess advertisements for further information about the position and how to apply.
We are recruiting an Early Stage Researcher to work on the implementation of high-resolution MRSI methods in a pre-clinical scanner as part of the INSPiRE-MED European project.
We seek a highly motivated and qualified individual as Early Stage Researcher for a three-year applied research project. The successful candidate will contribute to the development of advanced biomedical research tools in the field of Magnetic Resonance Spectroscopy and Imaging, and its application to the clinical day-to-day practice.
Project description: This position is one of the 15 ESR positions of the INSPiRE-MED European Training Network, which focuses on the development of Magnetic Resonance Spectroscopy (MRS) and MR Spectroscopic Imaging (MRSI) combined with Positron Emission Tomography (PET), enhanced by machine learning techniques.
The main aim of the PhD project (ESR4) will be the implementation of innovative high spatial resolution MRSI methods in a pre-clinical scanner. The ultimate goal will be the validation of optimal methods for improving imaging biomarker development of brain tumour in longitudinal studies of therapy response in mouse glioblastoma models. The project will involve evaluation of the methodology performance limits, repeatability and reproducibility compared to stock Bruker Biospec MRSI sequences and the assessment of speed-up MRSI methods in a 7-Tesla pre-clinical scanner.
We are recruiting an Early Stage Researcher to work on a decision-support system based on MRSI data at 3T, for glioblastoma therapy response follow- up,as part of the INSPiRE-MED European project.
We seek a highly motivated and qualified individual as Early Stage Researcher for a three-year applied research project. The successful candidate will contribute to the development of advanced biomedical research tools in the field of Magnetic Resonance Spectroscopy and Imaging, and its application to the clinical day-to-day practice.
Project description: This position is one of the 15 ESR positions of the INSPiRE-MED European Training Network, which focuses on the development of Magnetic Resonance Spectroscopy (MRS) and MR Spectroscopic Imaging (MRSI) combined with Positron Emission Tomography (PET), enhanced by machine learning techniques.
The main aim of the PhD project (ESR12) will be development of a Machine Learning medical decision-support system based on MRSI data at 3T, for glioblastoma therapy response follow-up.
The
ESR will develop a novel medical decision support system (MDSS)
focused on glioblastoma therapy response follow-up, based on magnetic
resonance spectroscopic imaging (MRSI) data, able to take and process
data from multiple MRSI formats and centres. For each patient’s
MRSI, the MDSS should deliver a nosological or classification image,
ready to be fused with images of other MR modalities from the same
patient. The DSS will be integrated into the interface of the
academic version of jMRUI, in a way that allows clinicians evaluate
the system with their data. An important part of of the project will
be the incorporation of automated MRSI artifact detection and removal
tools.
We are recruiting an Early Stage Researcher to work on the implementation of high-resolution MRSI methods in a pre-clinical scanner as part of the INSPiRE-MED European project.
We seek a highly motivated and qualified individual as Early Stage Researcher for a three-year applied research project. The successful candidate will contribute to the development of advanced biomedical research tools in the field of Magnetic Resonance Spectroscopy and Imaging, and its application to the clinical day-to-day practice.
Project description: This position is one of the 15 ESR positions of the INSPiRE-MED European Training Network, which focuses on the development of Magnetic Resonance Spectroscopy (MRS) and MR Spectroscopic Imaging (MRSI) combined with Positron Emission Tomography (PET), enhanced by machine learning techniques.
The main aim of the PhD project (ESR4) will be the implementation of innovative high spatial resolution MRSI methods in a pre-clinical scanner. The ultimate goal will be the validation of optimal methods for improving imaging biomarker development of brain tumour in longitudinal studies of therapy response in mouse glioblastoma models. The project will involve evaluation of the methodology performance limits, repeatability and reproducibility compared to stock Bruker Biospec MRSI sequences and the assessment of speed-up MRSI methods in a 7-Tesla pre-clinical scanner.
Jaca, 19th-24th June 2023
by Llenas M, Sandoval S, Costa PM, Oró-Solé J, 
