Abstract

A ¹H-¹H TOCSY experiment incorporating ¹³C multiplicity information is proposed. In addition, broadband ¹H homodecoupling in the indirect dimension can be implemented using a perfect BIRD module that affords exclusive ¹H chemical shift evolution with full decoupling of all heteronuclear and homonuclear (including ²J_HH) coupling constants. As a complement to the normal TOCSY and the recent PSYCHE-TOCSY experiments, this novel multiplicity-edited TOCSY experiment distinguishes between CH/CH₃ (phased up) and CH₂ (phased down) cross-peaks which facilitates resonance analysis and assignment.