All posts by Miquel

Prenatal cerebral and cardiac metabolic changes in a rabbit model of fetal growth restriction

Simões, Rui V., Miquel E. Cabañas, Carla Loreiro, Miriam Illa, Fatima Crispi & Eduard Gratacós. 2018. Assessment of prenatal cerebral and cardiac metabolic changes in a rabbit model of fetal growth restriction based on 13C-labelled substrate infusions and ex vivo multinuclear HRMAS. PLOS ONE 13(12). e0208784. DOI: 10.1371/journal.pone.0208784

Background: We have used a previously reported rabbit model of fetal growth restriction (FGR), reproducing perinatal neurodevelopmental and cardiovascular impairments, to investigate the main relative changes in cerebral and cardiac metabolism of term FGR fetuses during nutrient infusion.

Methods: FGR was induced in 9 pregnant New Zealand rabbits at 25 days of gestation: one horn used as FGR, by partial ligation of uteroplacental vessels, and the contralateral as control (appropriate for gestation age, AGA). At 30 days of gestation, fasted mothers under anesthesia were infused i.v. with 1-13C-glucose (4 mothers), 2-13C-acetate (3 mothers), or not infused (2 mothers). Fetal brain and heart samples were quickly harvested and frozen down. Brain cortex and heart apex regions from 30 fetuses were studied ex vivo by HRMAS at 4°C, acquiring multinuclear 1D and 2D spectra. The data were processed, quantified by peak deconvolution or integration, and normalized to sample weight.

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Job offer for the INSPiRE-MED project

We are recruiting an Early Stage Researcher to work on the implementation of high-resolution MRSI methods in a pre-clinical scanner as part of the INSPiRE-MED European project.

We seek a highly motivated and qualified individual as Early Stage Researcher for a three-year applied research project. The successful candidate will contribute to the development of advanced biomedical research tools in the field of Magnetic Resonance Spectroscopy and Imaging, and its application to the clinical day-to-day practice.

Project description: This position is one of the 15 ESR positions of the INSPiRE-MED European Training Network, which focuses on the development of Magnetic Resonance Spectroscopy (MRS) and MR Spectroscopic Imaging (MRSI) combined with Positron Emission Tomography (PET), enhanced by machine learning techniques.

The main aim of the PhD project (ESR4) will be the implementation of innovative high spatial resolution MRSI methods in a pre-clinical scanner. The ultimate goal will be the validation of optimal methods for improving imaging biomarker development of brain tumour in longitudinal studies of therapy response in mouse glioblastoma models. The project will involve evaluation of the methodology performance limits, repeatability and reproducibility compared to stock Bruker Biospec MRSI sequences and the assessment of speed-up MRSI methods in a 7-Tesla pre-clinical scanner.

Continue reading Job offer for the INSPiRE-MED project

INSPiRE-MED project awarded to GABRMN & SeRMN

Integrating Magnetic Resonance Spectroscopy and Multimodal Imaging for Research and Education in MEDicine (INSPiRE-MED) is an European research project awarded in the call H2020-MSCA-ITN-2018, of the MSCA-ITN-ETN – European Training Networks, to a consortium of partners including the GABRMN and SeRMN at UAB. The project is coordinated by Prof. Dominique Sappey-Marinier, of the Université Lyon-1 Claude-Bernard, Lyon, France. The scientist-in-charge at UAB will be Prof. Carles Arús (GABRMN), and Silvia Lope-Piedrafita (SeRMN) and Miquel Cabañas (SeRMN) will participate as senior scientists in the project.

Starting 1st of January 2019, the INSPiRE-MED Initial Training Network will investigate the theoretical and practical aspects of in vivo Magnetic Resonance Spectroscopy (MRS) and Spectroscopic Imaging (MRSI) with applications in oncology and neurology.

The network will host 15 Early Stage Researchers in the field of biomedical imaging, particularly in the field of Magnetic Resonance Spectroscopy (MRS) and MR Spectroscopic Imaging (MRSI) combined with Positron Emission Tomography (PET) and enhanced by machine learning techniques. The research training is supervised by a consortium of 12 academic partners with an established collaborative track record in R&D and 9 industrial partners from the broad and competitive preclinical and clinical imaging sector.

The main research topic to be carried at UAB —in close collaboration with other project members— will be the implementation of innovative high spatial resolution MRSI methods in a pre-clinical scanner. The ultimate goal will be the validation of optimal methods for improving imaging biomarker development of brain tumour in longitudinal studies of therapy response in mouse glioblastoma models.

Continue reading INSPiRE-MED project awarded to GABRMN & SeRMN

PhD Thesis: Edició crítica dels escolis al cant IX de l’Odissea, by Esperança Ramírez Sevilla

Last December, Esperança Ramírez, our facility secretary, defended her PhD Thesis entitled: “Edició crítica dels escolis al cant IX de l’Odissea” (Critical Edition of the Scholia to the Odyssey Book IX). The thesis defense took place at 11am on Friday 16 December in the Facultat de Filosofia i Lletres of Universitat Autònoma de Barcelona.

Scholia (singular scholium or scholion, from Ancient Greek: σχόλιον, “comment, interpretation”) are grammatical, critical, or explanatory comments, either original or extracted from pre-existing commentaries, which are inserted on the margin of the manuscript of an ancient author, as glosses.
Scholia definition in the Wikipedia

In her doctoral dissertation she does a thorough, critical and updated edition of the scholia to the Odyssey Book IX, including the scholia regarded as minor as well as the major scholia. This book and the following three books are collectively referred to as the apologoi: Odysseus’ “stories”, and they have attracted the attention of scholars of Homer works of all times.

To carry out her research work, she had to systematically analyse and challenge previous editions that, in full or in part, included scholia from the Odyssey Book IX, and, on the other hand, she had to decide the corpus of manuscripts that she would study, which was finally set to 37 from different typologies and genetic filiations.

Odyssey greek manuscript
Example of a handwritten manuscript studied in this thesis, the text of the Odyseey is on the left column, major scholia (comments) are on the right column, and minor scholia are interspersed in between the lines of the Odyssey text.

It stands out the methodological novelty of classifying the scholia according to their content: related to the titles, dedicated to argument summaries, focused on lexicographic aspects, contextual or mythographic. This classification, on top of helping to understand the content of each scholium, offers too an interesting view of the filiation of manuscripts.

Her goal was to offer a body of data encompassing the scholia, the annotations and also the most significant corrections of the Homeric text. In that corpus there are several types of content, from multiple versions of myths to words that must be construed, including syntactic expressions or morphological annotations.

The thesis is available for download from TESEO, the official repository of Spanish doctoral dissertations.

A translation of the Odyssey to English by A.T. Murray (1919) can be read on-line at the Classical Texts Library and another translation by Samuel Butler at The Internet Classics Archive. Also, if you are curious, you can hear how Homer’s Odyssey sounded in the original ancient greek, and if you dare so, you can take a free 64-lessons course to learn ancient greek.

Laura Castañar receives award at ENC 2015

Laura CastañarAward to Laura Castañar at the 56th ENC held in Asilomar from 19th to 24th April 2015. was honoured at the 56th Experimental Nuclear Magnetic Resonance Conference (ENC) with the Ritchey Travel Award for her Ph.D. Thesis research on “Development and application of modern pure shift NMR techniques and improved HSQC/HSQMBC experiments”The award ceremony took place at the After-Dinner Program in Asilomar Conference Center in Pacific Grove, California, USA, the 23th April, 2015.
Continue reading Laura Castañar receives award at ENC 2015

TRANSACT-ITN Scientific Workshop on “Spectra Classification and Decision-Support tools in the clinic”

Workshop on “Spectra Classification and Decision-Support tools in the clinic”
December 3-4, 2014 
Universitat Autònoma Barcelona, Spain

The TRANSACT European Project organizes a two-days scientific workshop on “Spectra Classification and Decision-Support tools in the clinic”. The workshop will be held on December 3-4, 2014 at Hotel Campus UAB which is located in the campus of Universitat Autònoma de Barcelona. Continue reading TRANSACT-ITN Scientific Workshop on “Spectra Classification and Decision-Support tools in the clinic”

Lilly Research Award to Laura Castañar

Laura Castañar is top finalist to the Lilly XII Research Awards for Graduate Students. The prize is awarded to ten Spanish young scientists, three awardees and seven finalists, for their research contributions in the field of chemistry. The awards ceremony took place at Lilly Research & Development Centre in Alcobendas, Madrid, Spain, the 26th September, 2014. Continue reading Lilly Research Award to Laura Castañar

Laura Castañar’s oral communication gets accessit award at GERMN 2014

Laura Castañar and Dr. Teodor Parella
Laura Castañar and Dr. Teodor Parella

Laura Castañar is honoured by JANSSEN with the accessit prize for her oral communication Enantiodifferentiation through Frequency-Selective Pure-Shift 1H NMR at the VII Biennial Meeting of the Nuclear Magnetic Resonance Group of the Spanish Royal Society of Chemistry / IV Iberian NMR Meeting / VI Ibero-American NMR Meeting (GERMN 2014) held in Alcalá de Henares, Spain, from 22nd to 24th September, 2014.

Continue reading Laura Castañar’s oral communication gets accessit award at GERMN 2014

Presentations at the Joint Annual Meeting ISMRM-ESMRMB 2014

Next week several SeRMN members will present our research work at the Joint Annual meeting ISMRM-ESMRMB 2014 that will take place in Milan (Italy) from 10th to 16th May. Find below a summary of our contributions.

Joint Annual Meeting ISMRM-ESMRMB

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CcpNmr Analysis – A useful tool for organic chemistry nmr?

SeRMN seminar

  • Date: Thursday 13th February, 2014
  • Hour: 10 am
  • Location: SeRMN, Facultats de Ciències i Biociències, C2/-135
  • Speaker: Miquel Cabañas, SeRMN

CcpNmr Analysis is a graphics-based interactive NMR spectrum visualisation, resonance assignment and data analysis program developed by The Collaborative Computing Project for NMR. as part of the CcpNmr suite of programs. Continue reading CcpNmr Analysis – A useful tool for organic chemistry nmr?