Tag Archives: cancer

Hyperpolarized 13C magnetic resonance metabolic imaging in a mouse brain glioma model

Magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized [1-13C]pyruvate is a promising technique to noninvasively monitor metabolic changes in vivo. This method uses dynamic nuclear polarization (DNP) techniques to obtain tens of thousands fold enhancement in the polarization of [1-13C]pyruvate and its metabolic products, like lactate, providing sufficient MR signal for high spatial and temporal resolution spectroscopic imaging of these metabolites. Continue reading Hyperpolarized 13C magnetic resonance metabolic imaging in a mouse brain glioma model