“Optimized polarization build-up times in dissolution DNP-NMR using a benzyl amino derivative of BDPA” by José Luis. Muñoz Gómez, Eva Monteagudo, Vega LLoveras, Teodor Parella, Jaume Veciana and José Vidal Gancedo. RSC Advances, 2016, 6, 27077. DOI: 10.1039/c6ra00635c
The synthesis of two novel BDPA-like radicals, a benzyl amino (BAm-BDPA, 7) and a cyano (CN-BDPA, 5) derivative, is reported and their behaviour as polarizing agents for fast dissolution Dynamic Nuclear Polarization (DNP) is evaluated. Continue reading Optimized polarization build-up times in dissolution DNP-NMR using a benzyl amino derivative of BDPA
“A Benzyl Alcohol Derivative of BDPA Radical for Fast Dissolution Dynamic Nuclear Polarization NMR Spectroscopy” by José Luis Muñoz Gómez, Eva Monteagudo, Vega Lloveras, Teodor Parella, Jaume Veciana and José Vidal Gancedo. Organic & Biomolecular Chemistry, 2015, 13:2689-2693. DOI: 10.1039/C4OB02356K
The synthesis, structural characterization and the successful application of a carbon centered radical derived from 1,3-bisdiphenylene-2-phenylallyl (BDPA), its benzyl alcohol derivative (BA-BDPA), as a polarizing agent for Dynamic Nuclear Polarization (DNP) are described. Continue reading A New Polarizing Agent for Dissolution-DNP
Dynamic Nuclear Polarization is the method for obtaining strongly polarised nuclear spins, resulting in enhanced NMR signals for 13C and 15N nuclei in solution-state
Our NMR facility (SeRMN) has recently installed a HyperSense® (Oxford Instruments), a new instrument capable of delivering a huge sensitivity enhancement for your in-vitro and in-vivo applications allowing an easy and quick switching between both applications.
Liquid-state NMR spectroscopy is an important technique into a wide range of applications. However, it is limited by an intrinsically lack of sensitivity due to the low gyromagnetic ratio and natural abundance of the nuclei usually under study (13C, 15N, etc.) as compared with other analytical methods. Continue reading What is DNP? Obtaining enhanced NMR signals for in-vitro and in-vivo applications