Kumar Motiram-Corral is presenting at SMASH 2021 Conference a talk entitled In situ Enantiospecific Detection of Multiple Metabolites in Mixtures using NMR Spectroscopy, related to some of our recent research work. The presentation will be 1st of September in the section “Unveiling the Unknown – New Methods in Structure Elucidation“.
Angew. Chem. Int. Ed., 2020 / doi:10.1002/anie.202011727
Chirality plays a fundamental role in nature, but its detection and quantification still face many limitations. To date, the enantiospecific analysis of mixtures necessarily requires prior separation of the individual components. The simultaneous enantiospecific detection of multiple chiral molecules in a mixture represents a major challenge, which would lead to a significantly better understanding of the underlying biological processes; e.g. via enantiospecifically analysing metabolites in their native environment. Here, we report on the first in situ enantiospecific detection of a thirty‐nine‐component mixture. As a proof of concept, eighteen essential amino acids at physiological concentrations were simultaneously enantiospecifically detected using NMR spectroscopy and a chiral solvating agent. This work represents a first step towards the simultaneous multicomponent enantiospecific analysis of complex mixtures, a capability that will have substantial impact on metabolism studies, metabolic phenotyping, chemical reaction monitoring, and many other fields where complex mixtures containing chiral molecules require efficient characterisation.
This work has been selected to be presented as a talk at 2021 scientific conferences:
· 42nd FGMR (German Chemical Society, Magnetic Resonance Section) Annual Discussion Meeting – Virtual, Sep 27 to Oct 1.
· SMASH- Small Molecule NMR Conference 2021 – Virtual, Aug 30 to Sep 2.
· Euromar 2021 Conference – Virtual, 5 to 8 July.
· 10th GERMN (Spanish NMR group of the Real Sociedad Española de Química) biennial & 9th IberoAmerican NMR Meeting – Virtual, 26 to 19 April.
Applications are welcome for a four-year PhD position in the field of high-resolution NMR spectroscopy at the NMR Service (SeRMN) of the Universitat Autònoma of Barcelona (UAB).
The researcher will investigate the subject “Analysis of complex mixtures by NMR spectroscopy” under the joint supervision of Dr. Teodor Parella and Dr. Míriam Pérez-Trujillo, as part of the project “Design and Application of New Methodologies in Nuclear Magnetic Resonance” (Diseño y aplicación de nuevas metodologías en resonancia magnética nuclear, CTQ2015-64436-P, 2016-2018) awarded to Dr. Teodor Parella.
This scholarship is awarded by the Spanish Ministry of Economy and Competitiveness (MINECO), through the Predoctoral Research Fellowship Program (*) and it is co-funded by the European Social Fund (ESF).
The call for applications begins September 13th, 2016, and the deadline for submissions is September 27th, 2016 at 15:00.
All information relating to the call for applications is available at the MINECO web site and at the Database of Spanish National Funding. For details or questions about the research project, contact Dr. Teodor Parella.
(*) Convocatoria de Ayudas para contratos predoctorales para la formación de doctores 2016. Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016. Programa Estatal de Promoción del Talento y su Empleabilidad, Subprograma Estatal de Formación.
The Spanish Ministry of Economy and Competitiveness (MINECO) has open the call for FPI-funded PhD thesis. At the time, applications are welcome for an FPI (Formación de Personal Investigador)-funded PhD thesis (4 years) associated to the project “NUEVOS MÉTODOS EN RESONANCIA MAGNÉTICA NUCLEAR (IV)” (Novel methodologies in Nuclear Magnetic Resonance (IV) – ref: CTQ2012-32436) at the SeRMN in the Universitat Autònoma of Barcelona (UAB). FPI fellowships are granted by the Spanish Ministry of Economy and Competitiveness.
The call for applications begins August 26th, 2013, and the deadline for submission of applications is September 10th, 2013 at 15:00. All information relating to the call for applications can be found the at Minister’s web page or contact to for further details or questions.