All posts by Silvia

Neurodegeneration in NPC Mice by T2 and DTI MRI

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“In Vivo Assessment of Neurodegeneration in Niemann-Pick Type C Mice by Quantitative T2 Mapping and Diffusion Tensor Imaging”, by John W. Totenhagen, Silvia Lope-Piedrafita, Ivan A. Borbon, Eriko S. Yoshimaru, Robert P. Erickson, and Theodore P. Trouard; Journal of Magnetic Resonance Imaging 35 (2012), 528-536. doi: 10.1002/jmri.22837

NIEMANN-PICK TYPE C (NPC) disease is a rare genetic neurodegenerative disease with no cure and few effective options for treatment. Diagnosis is most often made during childhood with symptoms progressively worsening and leading to death prior to adulthood. Continue reading Neurodegeneration in NPC Mice by T2 and DTI MRI →

7th Workshop on Magnetic Resonance Spectroscopy and Imaging (MRI/MRS) Applied to Laboratory Animals

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Dates:  24th -27th October 2011

Organized by the SeRMN of the Autonomous University of Barcelona (UAB).

This workshop combines a comprehensive series of lectures on the technology of magnetic resonance spectroscopy and imaging (MRS/MRI) with hands-on laboratory sessions to provide practical demonstrations of key concepts and procedures for preclinical studies.

Whether you are considering MRI as a research tool in your lab or just would like to learn more about MRI, this workshop addresses practical aspects of experimental MRI with laboratory animals and provide valuable hands-on experience on a 7 T Bruker BioSpec spectrometer.

Number of participants will be limited to 4.

For the registration, please fill the Registration Form and email it to ,  registration deadline ends October 10th.

See Workshop Brochure for more information or contact Silvia Lope via email.

Hyperpolarized 13C magnetic resonance metabolic imaging in a mouse brain glioma model

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Magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized [1-13C]pyruvate is a promising technique to noninvasively monitor metabolic changes in vivo. This method uses dynamic nuclear polarization (DNP) techniques to obtain tens of thousands fold enhancement in the polarization of [1-13C]pyruvate and its metabolic products, like lactate, providing sufficient MR signal for high spatial and temporal resolution spectroscopic imaging of these metabolites. Continue reading Hyperpolarized 13C magnetic resonance metabolic imaging in a mouse brain glioma model →