SeRMN presentations at the 2014 Ibero-American NMR & GERMN Bienal & Iberian NMR meeting

Imagen1Some of our last research work will be presented next week at the VI Ibero-American NMR – VII GERMN Bienal – IV Iberian NMR joint meeting that will take place in Alcalá de Henares, Madrid (Spain) from 22nd to 25th September. Find below a summary of our contributions.

Laura Castañar presents an oral communication and a poster entitled “Enantiodifferentiation throgh frequency-selective pure shift 1H NMR”.  NMR-aided discrimination of enantiomers using chiral solvating agents (CSAs) is a well established method to carry out enantiodifferentiation studies. The analysis is traditionally performed by observing chemical shift differences (ΔΔδ) in 1H signals by conventional 1D 1H NMR spectra. However signals overlapping caused by low ΔΔδ values and homonuclear scalar couplings (JHH) lead to the lack of spectral signal dispersion that preclude a straightforward analysis. Recently, pure shift NMR spectroscopy has emerged as a promising tool to simplify the typical JHH multiplicity pattern of 1H signals to singlets. This affords a general improvement on signal dispersion that allows an improved analysis of complex and overcrowded resonances. Based on the full-sensitive 1H-HOBS experiment, frequency-selective technique for the fast and simple discrimination of ΔΔδ in overlapped signals and for the determination of the R/S molar ratio in the presence of CSAs is here proposed.

© 2014 – 2015, Laura. All rights reserved by the author(s) and Universitat Autonoma de Barcelona except for texts and images already copyrighted by third parties (e.g. journal publishers) and used here under the fair use provision.