Intracranial hypertension is a severe complication of acute liver failure (ALF) secondary to brain edema. The pathogenesis of cerebral edema in ALF is not clear, but seems to be related to energy metabolism in which lactate may have an important role. The aim of this study was to follow the synthesis of brain lactate using a novel in vivo metabolic technology in a rat model of ALF. Continue reading Hyperpolarized 13C Magnetic Resonance in Acute Liver Failure Rats→
“A new ex vivo method to evaluate the performance of candidate MRI contrast agents: a proof-of-concept study” by Candiota A.P., Acosta M., Simões R.V., Delgado-Goñi T., Lope-Piedrafita S., Irure A., Marradi M., Bomatí-Miguel O., Miguel-Sancho N., Abasolo I., Schwartz S. Jr., Santamaría J., Penadés S., Arús C. J Nanobiotechnology2014 12:12. DOI: 10.1186/1477-3155-12-12.
A new method has been developed for selecting MRI contrast agents with better expected in vivo performance. This method requires only a very small amount of contrast agent (e.g. 5 nmols/animal, 800 times less than the quantity necessary for in vivo administration) and allows to carry out a more rationally informed candidate selection, avoiding unnecessary in vivo and toxicology tests for the ex vivo poorly performing substances, consequently reducing animal needs, material consumption and overall costs. Continue reading Ex vivo method to evaluate MRI contrast agents→
“Factors Secreted by Endothelial Progenitor Cells Enhance Neurorepair Responses after Cerebral Ischemia in Mice” by Rosell, A., Morancho, A., Navarro-Sobrino, M., Martínez-Saez, E., Hernández-Guillamon, M., Lope-Piedrafita, S., Barceló, V., Borrás, F., Penalba, A., García-Bonilla, L., Montaner, J. PLoS ONE 8 (2013), e73244. DOI: 10.1371/journal.pone.0073244
Organized by the SeRMN of the Autonomous University of Barcelona (UAB).
This workshop combines a comprehensive series of lectures on the technology of Magnetic resonance spectroscopy and imaging (MRS/MRI) with hands-on laboratory sessions to provide practical demonstrations of key concepts and procedures for preclinical studies.
Whether you are considering MRI as a research tool in your lab or just would like to learn more about MRI, this workshop addresses practical aspects of experimental MRI with laboratory animals and provide valuable hands-on experience on a 7 Tesla Bruker BioSpec spectrometer.
Number of participants will be limited to 4.
For the registration, please fill the Registration Form and email it to email@example.com (registration deadline ends May 27st)
“Brain magnetic resonance in experimental acute-on-chronic liver failure” by L. Chavarria, M. Oria, J. Romero-Giménez, J. Alonso, S. Lope-Piedrafita, and J. Cordoba. Liver International 33 (2013) 294-300. DOI: 10.1111/liv.12032
Liver failure causes brain edema that can lead to intracranial hypertension and death. It is currently uncertain whether this water accumulation is predominantly intracellular or extracellular, something important to determine in order to apply the most adequate therapeutic measures. The aim of this study was to investigate the mechanisms involved in the neurological manifestations occurring in an experimental acute-on-chronic liver failure rat model that combines sustained liver injury with a factor inducing an inflammatory response.
We are recruiting an Early Stage Researcher to work on the Development of Decision Support System & Spectral Classification tool meta-plug-ins for the jMRUI platform as part of the TRANSACT-ITN European project.
We seek a highly motivated and qualified individual as Early Stage Researcher for a three-year applied research project. The successful candidate will contribute to the development of advanced biomedical research tools in the field of Magnetic Resonance Spectroscopy and Imaging, and its application to the clinical day-to-day practice.
The position is intended for a young post-graduate student/researcher, with a Master degree or equivalent on Engineering or Computer Science, and with a proficient knowledge of the Java programming language. Prior experience on signal and/or image processing, segmentation and pattern recognition applications in the field of biomedical research is an asset, particularly in the field of Magnetic Resonance Spectroscopy and/or Imaging.
Transforming Magnetic Resonance Spectroscopy into a Clinical Tool (TRANSACT) is an European research project awarded in the call FP7-PEOPLE-2011-ITN, of the 7th Framework Programme Marie-Curie Actions, to a network of partners including the GABRMN and SeRMN at UAB, and the associated partner CIBER-BBN. The project is coordinated by Prof. Sabine Van Huffel, Prof. Uwe Himmelreich, and Dr. Diana Sima, of the Department of Electrical Engineering ESAT-SCD, and Department of Imaging & Pathology, Biomedical MRI Unit, Katholieke Universiteit Leuven, Leuven, Belgium. Scientist-in-charge at UAB will be Prof. Carles Arús (GABRMN) and Miquel Cabañas (SeRMN), and Dr. Margarida Julià-Sapé will be scientist-in-charge at CIBER-BBN. Dr. Silvia Lope-Piedrafita (SeRMN) will take part in the project as senior scientist.
“Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart” by A. Planavila, E. Dominguez, M. Navarro, M. Vinciguerra, R. Iglesias, M. Giralt, S. Lope-Piedrafita, J. Ruberte, F. Villarroya. Journal of Molecular and Cellular Cardiology 53 (2012) 521-531. DOI: 10.1016/j.yjmcc.2012.07.019
The protein deacetylase Sirtuin-1 (Sirt1) is involved in the cardiac hypertrophic responses and cardiac embryo morphogenesis. However, the physiological function of Sirt1 deficiency in the postnatal development of the heart remains to be characterized. The aim of this study was to investigate the relevance of Sirt1 in the development and function of the myocardium by using complementary techniques, such as gene expression, immunoblotting, immunohistochemistry, histological and electron microscopy examinations, and in vivo cardiac magnetic resonance imaging (MRI).
“Dimethyl sulfoxide (DMSO) as a potential contrast agent for brain tumors”, by Delgado-Goñi T, Martín-Sitjar J, Simões RV, Acosta M, Lope-Piedrafita S, Arús C.; NMR in Biomedicine. 2012.
Identifying the type of brain tumor helps doctors determine the most appropriate course of treatment. Brain tumor diagnosis usually involves a neurological examination, brain scans, and/or an analysis of the brain tissue. Nowadays, the biopsy, although it is a very invasive procedure, is the most accurate method of obtaining a diagnosis. Continue reading DMSO as a magnetic resonance contrast agent for brain tumors→
“Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents”, by Cavalli S, Carbajo D, Acosta M, Lope-Piedrafita S, Candiota AP, Arús C, Royo M, Albericio F; Chem. Commun 48(2012) p. 5322. DOI: 10.1039/C2CC17937G
Recent advances in nanotechnology have offered new opportunities for detection, prevention, and treatment of different diseases. In this respect engineered superparamagnetic iron oxide nanoparticles (SPIONs) represent an advanced tool in nanomedicine because they can be loaded in a multiple and orthogonal way with drugs and probes in order to simultaneously act as molecular imaging agents and drug carriers. Continue reading Novel MRI contrast agents: peptide-SPION conjugates→