Category Archives: Our Publications

These are the scientific articles published by SeRMN personnel. Posts may contain a short description of the research work objective and relevance, in addition to the abstract of the article, the bibliographic reference, and the article DOI if available.

Ca(BH4)2 + MgH2: Desorption Reaction

Our Publications, , , ,

jpccck_v117i005.indd“Ca(BH4)2 + MgH2: Desorption Reaction and Role of Mg on its Reversibility” by Christian Bonatto Minella, Claudio Pistidda, Sebastiano Garroni, Pau Nolis, Maria Dolors Baró, Oliver Gutfleisch, Thomas Klassen, Rüdiger Bormann, and Martin Dornheim. The Journal of Physical Chemistry C. 117:3846-3852 (2013). DOI: 10.1021/jp312271s

The Ca(BH4)2-MgH2 composite system represents a promising candidate for mobile hydrogen storage due to a 10.5 wt. % theoretical hydrogen storage capacity and an estimated equilibrium temperature lower than 160 °C. For this system, the reversibility was achieved without further addition of additives. Continue reading Ca(BH4)2 + MgH2: Desorption Reaction →

Brain magnetic resonance in liver failure

Methods & Applications, Our Publications, Our Research, , , ,

“Brain magnetic resonance in experimental acute-on-chronic liver failure” by L. Chavarria, M. Oria, J. Romero-Giménez, J. Alonso, S. Lope-Piedrafita, and J. Cordoba.
Liver International 33 (2013) 294-300. DOI: 10.1111/liv.12032

Liver failure causes brain edema that can lead to intracranial hypertension and death. It is currently uncertain whether this water accumulation is predominantly intracellular or extracellular, something important to determine in order to apply the most adequate therapeutic measures. The aim of this study was to investigate the mechanisms involved in the neurological manifestations occurring in an experimental acute-on-chronic liver failure rat model that combines sustained liver injury with a factor inducing an inflammatory response.

Continue reading Brain magnetic resonance in liver failure →

Cardiac MRI of the Sirt1-deficient mouse heart

Methods & Applications, Our Publications, ,

“Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart”
 by A. Planavila, E. Dominguez, M. Navarro, M. Vinciguerra, R. Iglesias, M. Giralt, S. Lope-Piedrafita, J. Ruberte, F. Villarroya. Journal of Molecular and Cellular Cardiology 53 (2012) 521-531. DOI: 10.1016/j.yjmcc.2012.07.019

The protein deacetylase Sirtuin-1 (Sirt1) is involved in the cardiac hypertrophic responses and cardiac embryo morphogenesis. However, the physiological function of Sirt1 deficiency in the postnatal development of the heart remains to be characterized. The aim of this study was to investigate the relevance of Sirt1 in the development and function of the myocardium by using complementary techniques, such as gene expression, immunoblotting, immunohistochemistry, histological and electron microscopy examinations, and in vivo cardiac magnetic resonance imaging (MRI).

Continue reading Cardiac MRI of the Sirt1-deficient mouse heart →

P.E.HSQMBC: Simultaneous measurement of proton–proton and proton–carbon coupling constants

Methods & Applications, Our Publications, Our Research, , , , ,

“P.E.HSQMBC: Simultaneous measurement of proton–proton and proton–carbon coupling constants” by Josep Saurí, Pau Nolis, Laura Castañar, Albert Virgili and Teodor Parella. Journal of Magnetic Resonance 224 (2012) 101–106. DOI: 10.1016/j.jmr.2012.09.007

A long-range optimized P.E.HSQC experiment, named P.E.HSQMBC, is proposed for the simultaneous measurement of a complete set of homonuclear and heteronuclear coupling constants from a single 2D cross-peak. Continue reading P.E.HSQMBC: Simultaneous measurement of proton–proton and proton–carbon coupling constants →

Tuberculosis mycobacterium and microscopic cords formation. Related to their virulence

Methods & Applications, Our Publications,

“Cyclopropanation of α-mycolic acids is not required for cording in non-tuberculous mycobacteria” Cecilia Brambilla, Alejandro Sánchez-Chardi, Míriam Pérez-Trujillo, Esther Julián, Marina Luquin.  Microbiology, March 2012. DOI: 10.1099/mic.0.057919-0

Mycobacterium tuberculosis and Mycobacterium bovis are the principal agents responsible for human tuberculosis and tuberculosis in domestic and wild animals. Both form microscopic cords, a phenotypic characteristic that has been related to their virulence. The compounds responsible for cording are unknown, but a recent work has shown that cording could be related to the fine structure of α-mycolic acids. Continue reading Tuberculosis mycobacterium and microscopic cords formation. Related to their virulence →

HSQMBC-COSY: Measurement of the sign and the magnitude of long-range proton-carbon coupling constants

Methods & Applications, Our Publications, Our Research, , ,

“Efficient measurement of the sign and the magnitude of long-range proton-carbon coupling constants from a spin-state-selective HSQMBC-COSY experiment”, by Josep Saurí and Teodor Parella; Magn. Reson. Chem. 2012, 50, 717-721. DOI:10.1002/mrc.3867

A spin-state-selective HSQMBC-COSY experiment is proposed to measure the sign and  the magnitude of long-range proton-carbon coupling constants (nJ(CH); n>1) either for protonated and for non-protonated carbons in small molecules. Continue reading HSQMBC-COSY: Measurement of the sign and the magnitude of long-range proton-carbon coupling constants →

Metabolic profiling for the detection of early effects of environmental and lifestyle exposure to cadmium.

Methods & Applications, Our Publications, ,

“Metabolic Profiling Detects Early Effects of Environmental and Lifestyle Exposure to Cadmium in a Human Population” JK Ellis, TJ Athersuch, LDK Thomas, F Teichert, M Pérez-Trujillo, C Svendsen, D J. Spurgeon, R Singh, L Järup, JG Bundy and HC Keun.  BMC Medicine, February 2012.  DOI: 10.1186/1741-7015-10-61

The ‘exposome’ represents the accumulation of all environmental exposures across a lifetime. Top-down strategies are required to assess something this comprehensive, and could transform our understanding of how environmental factors affect human health. Metabolic profiling (metabonomics / metabolomics)  defines an individual’s metabolic phenotype, which is influenced by genotype, diet, lifestyle, health and xenobiotic exposure, and could also reveal intermediate biomarkers for disease risk that reflect adaptive response to exposure. Continue reading Metabolic profiling for the detection of early effects of environmental and lifestyle exposure to cadmium. →

Chiral secondary structure in β-peptides determined by NMR

Our Publications, , , , ,

“Secondary Structure of Short β-Peptides as the Chiral Expression of Monomeric Building Units: a Rational and Predictive Model”Esther Gorrea, Gabor Pohl, Pau Nolis, Sergio Celis, Kepa K Burusco, Vicenç Branchadell, András Perczel, and Rosa M. Ortuño. Journal Of Organic Chemistry. ACCEPTED 2012 DOI: 10.1021/jo302034b

Chirality of the monomeric residues controls and determines the prevalent folding of small oligopeptides (from di- to tetramers) composed of the 2-aminocyclobutane-1-carboxylic acid (ACBA) derivatives with the same or different absolute and relative configuration. The cis-form of the monomeric ACBA gives rise to two conformers, namely Z6 and Z8, while the trans-form manifests uniquely as an H8 structure.  Continue reading Chiral secondary structure in β-peptides determined by NMR →

How does HR-MAS spin rate affect the spectral pattern of mobile lipids?

Our Publications, Our Research, , ,

“Influence of the spinning rate in the HR-MAS pattern of mobile lipids in C6 glioma cells and in artificial oil bodies” Juana Martín-Sitjar, Teresa Delgado-Goñi, Miquel E. Cabañas, Jason Tzen, Carles Arús; Magnetic Resonance Materials in Physics, Biology and Medicine, 2012, 25(6):487-496. DOI: 10.1007/s10334-012-0327-6

Object: To evaluate how spinning rate affects mobile lipid (ML) resonances visibility in HR-MAS spectra of C6 glioma cells and artificial oil bodies (AOB), as models of cytosolic lipid droplets. Materials and methods: Using C6 cells and AOB of two different sizes, 780 ± 580 and 240 ± 293 nm, as models, we acquired HR-MAS pulse and acquire spectra at different spinning rates between 500 and 15,000 Hz, all at 37 °C. Continue reading How does HR-MAS spin rate affect the spectral pattern of mobile lipids? →

Presentations to the Ibero-American NMR & GERMN Bienal & Iberian NMR joint meeting

News from the SeRMN, NMR Events & Courses, Our Publications, Our Research, , , , , , ,

Next week several SeRMN members will present our research work at the IV Ibero-American NMR – VI GERMN Bienal – III Iberian NMR joint meeting that will take place in Aveiro (Portugal) from 25th to 28th September. Find below a summary of our contributions.

Continue reading Presentations to the Ibero-American NMR & GERMN Bienal & Iberian NMR joint meeting →